evaluable: meaning, origin, definition - WordSense Dictionary ASCO Proceedings (pp This dose level was the used for the feasibility phase. Mean total PANSS: 58.8 vs 61.7 at 6 mo. Pharmaceutical Compositions - ASTRAZENECA AB Within the first 4 cycles, seven (35%) of twenty evaluable patients had dose-limiting toxicities (DLTs) including grade 4 thrombocytopenia (1), grade 3 neutropenic fever (3 . 5 Ways to Become an Invaluable Asset ... - Balanced WorkLife Two were unevaluable for dose-limiting toxicity due to port complications. Regenerative and Cell Therapy: Clinical Advances (Ernst ... Unevaluatable vs. Unevaluable. In all, 28 of 38 (74%) evaluable patients attained CR. Toxicity for the feasibility phase is shown in Table 4. We therefore believe that based on outcomes of our study, intratumoral EBUS guided injection of cisplatin can represent a new management paradigm for these patients with isolated No patient progressed on RCHOP therapy. Free essays, homework help, flashcards, research papers, book reports, term papers, history, science, politics Mean age at the starting of bDMARD was 53.1 ± 13.3 years. Based on the recommended phase II doses for doxorubicin (60 mg/m2) and docetaxel (60 mg/m2) and the National Surgical Adjuvant Breast and Bowel Project's (NSABP) experience with doxorubicin and cyclophosphamide (cyclophosphamide 600 mg/m2), we Invaluable adjective. Comment décrivons-nous « quelque chose qui peut être évalué »? Of the 53 eligible cases for Step 2 RIT, 48 (90%) registered. AALL0434 enrolled 299 patients with T-LL (2010-2014). *, II.4: *:I kon him thanks that he hath had the hap to chuse, and knowledge to cull-out so worthy a worke, and a booke so fit to the purpose, therewith to make so unvaluable a present unto his Countrie. 53% (28/53) of patients received growth factors, 42% (22/53) had a dose modification of CHOP and 13 (25%) had a modification of their rituximab dose. Survey of 18 dose-escalation studies. The reasons for withdrawal were adverse events (n=1), refusal (n=2), physician discretion (n=1), and insurance company refusal (n=1). 53 (9.9%) patients not evaluable. Objectives The aim of this study is to define the maximal safe radiation dose to guide further study of the GliaSite balloon brachytherapy (GSBT) system in untreated newly diagnosed glioblastoma (NEW-GBM) and recurrent high-grade glioma (REC-HGG). It is also evident that scarce resources should shift away from unfocused advocacy and awareness-raising regarding isolated "success stories" (which may or may not be replicable in other contexts or which have gone largely unevaluated) towards a much more complex response. Patients received docetaxel (55-75 mg/m 2) IV and carboplatin (AUC 5-7) IP on day 1 and paclitaxel 60 mg/m 2 IP on day 8. Not evaluable. Cependant, « évaluable » est apparemment le mot qui signifie «pouvant être évalué» et non «évaluable». Be someone that your co-workers appreciate and enjoy . One patient died of herpes encephalitis. ERK phosphorylation was induced in stromal cell co-cultures and was refractory to inhibition in response to . The MTD was estimated at carboplatin AUC 6 IP and 25 patients enrolled at this dose level. INTRODUCTION. ADVERTISEMENT. A Survey on DLT-Unevaluable Patients. Not evaluable . Six patients were not evaluable due to hypersensitivity reaction (1), progressive disease (1), patient refusal (1) and surgical complications requiring . 2.1 SPI presupposition: definite descriptions It is plausible, if somewhat controversial, that both definite descriptions of the form Strive to remain positive in your daily interactions at work. Adjective. Not able to be evaluated. Five of 44 enrolled patients were ineligible due to choriocarcinoma and normal pretreatment serum hCG level (2 each), no history of methotrexate (1), and 1 patient with documented phantom hCG syndrome was unevaluable. 55.3 vs 57.1 at 12 mo. Don't backbite, gossip, or get involved with needless office politics. Y a-t-il une raison particulière à cette différence apparente, ou . A method of treating a patient suffering from or susceptible to a Mood Disorder or an Anxiety Disorder comprising administering a sustained release pharmaceutical composition comprising a pharmaceutically effective amount of 11-[4-[2-(2-hydroxyethoxy)ethyl]-1-piperazinyl]dibenzo-[b,f][1,4]thiazepine, or a pharmaceutically acceptable salt thereof to the patient in need . REFERENCES: Hammer S et al. (rare) Not valuable; having little value. The dose range of LY3076226 tested was 0.2-5.0 mg/kg as an intravenous infusion on Day 1 of each 21-day cycle. Tables 2 and 3 show the tumor characteristics of the two cohorts. The antonym for valuable is worthless. toxicity and replaced. One subject had a complete response at the end of IV . Mean QWB: Valuable refers to something worth a lot of money, whereas invaluable refers to something having inestimable value beyond the monetary value. intraperitoneal port-related complications were considered inevaluable for dose-limiting . Being an expert will make you valuable to your employers, but being a role model could make you valuable to everyone at the company. Those patients receiving radiation had a better response rate (55% vs 31%, P = .016) but . Also, demographic and serologic data of RA patients were reported.Results:A total of 776 (776/2080, 37.3%) RA patients, who was prescribed a second biological agent, was registered in HUR-BIO by the end of 2020. Valuable can be used as adjective and noun, whereas invaluable only works as an adjective. None of the remaining 6 patients had a DLT during the first cycle. Valuable means of considerable value, and invaluable means incapable of being valued. unevaluable (not comparable) Examples Stem. Transplantation 47:1087±1089 Thomson JA, Itskovitz-Eldor J, Shapiro SS, Waknitz MA, Swiergiel JJ, Marshall VS, Jones JM (1998) Embryonic stem cell lines derived from human blastocysts (comment). Seven of 11 patients (67%) with known pathologic . Six were unevaluable. Seventeen were subsequently deemed ineligible/unevaluable, leaving 282 patients who were evaluable for induction (Appendix Table A2, online only), including 95 SR and 180 HR patients, 3 patients with IF, and 4 unknowns . 14 (77.8%) studies had at least 1 unevaluable patient. What is claimed is: 1. Upon completion of planned chemotherapy post-SPP instillation, the PFS at 6 months was 66% (4/6) and at 12-months 66% (4/6) using RECIST 1.1. Tumour response after RCHOP was 79% (42/53) CR/CRu and 19% (10/53) PR; one case was inevaluable. Unevaluable owing to insufficient data reported: Valenstein et al 16 (2009) USA: Serious mental illness and MPR <80%: MPR: 91% vs 64% at 6 mo. * { {quote-journal, 2009, date=February 6, Robert M. May & Paul H. Harvey, Species Uncertainties, Science citation. This was reflected both in clinical T classification (75% of all bilateral tumors were T1 vs. 59% of unilateral tumors, P = 0.04) and in the median pathologic tumor size (1.2 cm vs. 1.7 cm, P = 0.02). The median number of cycles was 4 (range, 2-10). Results: Geriatric patients constituted 832/3748 (22.20%) of our work load. Unvaluable adjective. If you need an opposite of valuable, there are many options such as inexpensive , cheap, and worthless . An inhibitory effect of stromal cells on in vitro megakaryopoiesis occurs both with primary human CD34 + cells and erythroleukemic cell line model systems.6,7 The stromal inhibition of megakaryocyte production from CD34 + cells clearly requires direct cell-cell contact.8 This inhibitory effect may partly account for the impaired megakaryocytic engraftment frequently seen after bone marrow . Jewels, watches, cars are valuable, whereas a good friend is invaluable. beyond calculable or appraisable value; of inestimable worth; priceless: an invaluable art collection; her invaluable assistance. Unvaluable adjective. Six were unevaluable. Evaluable vs. Evaluable. Fifteen evaluable patients had dose- . Six patients were evaluable due to one subject who had unevaluable scans throughout the follow-up period and was thus excluded from PFS determination. At 5 years, 78% of patients remain in remission and 94% are alive. In all, 28 of 38 (74%) evaluable patients attained CR. Invaluable; being beyond price. inevaluable (comparative more inevaluable, superlative most inevaluable) Unable to be evaluated. Ten patients were in PR after RCHOP. Very useful. Proportion with positive composite adherence measure †: 50% vs 17% at 6 mo. Don't backbite, gossip, or get involved with needless office politics. The best response after RCHOP+RIT in all 53 patients was a functional CR rate of 89% (47/53; 95% CI:77-96%). Being an expert will make you valuable to your employers, but being a role model could make you valuable to everyone at the company. Grade 3 adverse events (AE) occurred in 43% of pts and grade 4 AE in 10%, primarily hematologic, constitutional or gastrointestinal (nausea, anorexia) toxicity. Valuable and invaluable do mean similar things, but the in- in invaluable isn't playing any tricks. Five of 44 enrolled patients were ineligible due to choriocarcinoma and normal pretreatment serum hCG level (2 each), no history of methotrexate (1), and 1 patient with documented phantom hCG syndrome was unevaluable. unevaluable at worlds, or the character of a is unevaluable at ->'¡/ contexts.3 To illustrate the meaning of clauses (SPI) and (SP2), I will describe some examples. 5th Euro Conf on Clin Aspects and Treat of HIV Infect, Copenhagen, 1995. Response to neoadjuvant treatment was . Become a Role Model. Retrouvez la définition du mot inévaluable dans notre dictionnaire en ligne par la-conjugaion.fr. The median number of cycles was 4 (range, 2-10). Patients with bilateral tumors were more likely to present with smaller tumors. In a randomized study 145 patients with extensive small cell carcinoma of the lung were treated with chemotherapy alone (Cytoxan, CCNU, methotrexate) or with the same drug regimen and with radiation therapy to the brain, chest, and abdomen. 86% vs 62% at 12 mo. Of these patients, 83.7% was female. However, the presence of clavicular fractures (resulting in incomplete radiographs in 68% vs. 34% without a fracture; p < 0.001) and rib fractures (56% vs. 34%; p = 0.008) were associated with . Subsequent cycles . No difference in OS rates for pts with 3, 4 or 5 high risk factors was seen. Methods This study was comprised of two parts: (A) dose escalation in patients with advanced or metastatic cancer and (B) dose expansion in patients with urothelial carcinoma with locally determined FGFR3 alterations. ( en adjective ) Not able to be evaluated. The aim of this study was to determine the efficacy of cisplatin, ifosfamide, and mesna in uterine malignant mixed müllerian tumor (MMMT) and to evaluate the expression of clinically relevant molecular markers. Ixabepilone and the taxanes have similar activity in the first-line treatment of metastatic breast cancer, and ixabepilone is sometimes effective in taxane-refractory patients. FASEB J 7:1061±1069 Tai J, Johnson HW, Tze WJ (1989) Successful transplantation of Leydig cells in castrated inbred rats. To shorten everything, "valuable" refers to something that has a great value, usually in money, whereas "invaluable" is somehow a synonym for "valuable", not an opposite, referring to something even more "valuable", something very useful. Rate this article: (3.87 / 7 votes) Email Print. Define inevaluable. 0.06. These DLTs were prolonged neutropenia (2), neutropenic fever (7), grade 4 thrombocytopenia (1), grade 4 dehydration (1), grade 3 infection (2), grade 3 oral mucositis (1) and pulmonary embolism (1). inevaluable: inevaluable (English) Origin & history in- + evaluable. Males 432 (51.92%) Females 400 (48.08%). Average delay of 20.53 days per unevaluable patient (range: 0-51 days) invaluable: [adjective] valuable beyond estimation : priceless. Evidence supporting the role of hematopoietic stem cell transplantation (SCT) in the therapy of multiple myeloma (MM) is presented and critically evaluated in this systematic evidence-based review. Specific criteria were used for searching the published medical literature and for grading the quality of the evidence, the strength of the evidence, and the strength of the treatment recommendations. expected and the results were judged to be negative or unevaluable. We conducted a phase 2 trial to evaluate ixabepilone in combination with cyclophosphamide as neoadjuvant treatment for patients with locally advanced HER2-negative breast cancer. Be someone that your co-workers appreciate and enjoy . Of patients with radiologically evaluable disease at . 35% vs 18% at 12 mo <0.0001 <0.0001. Four of the five cases with CRu going into RIT converted to CR; one was inevaluable. Ma première pensée a été « évaluable », puisque nous avons. Definition from Wiktionary, the free dictionary Invaluable We think of valuable as meaning "having a great deal of value," as in "valuable jewelry" or "learned a valuable lesson." 3 year PFS was 59.2% (95% CI:50.7-67.8%). Of these, 82 SR patients, 121 HR patients and 2 patients defined as IF . Of the 35 cases with CR going into RIT, 97% (34/35) remained CR; 1 progressed. Results: Co-culture with stromal cells provided significant protection from cell death induced by MRX-2843 treatment (no co-culture vs. co-culture: Kasumi-1: 61.2% vs. 31.9% dead, OCI-AML5: 79.1% vs. 25.8%, C1498: 66.0% vs. 42.3%). It simply means "not." Valuable vs. One hundred eighteen of these patients were evaluable. GBST is a balloon placed in the resection cavity and later filled through a subcutaneous port with liquid I-125 Iotrex, providing radiation doses . The answer: yes and no. Adjective inevaluable (comparative more inevaluable, superlative most inevaluable) Unable to be evaluated. Become a Role Model. Twenty-six patients were enrolled in the first stage of feasibility at Dose Level IV. Strive to remain positive in your daily interactions at work. Grade 3-4 sensory neurotoxicity was more common in arm A (1.9 vs 0%) and grade 3-4 diarrhoea was more common in arm B (0.6 vs 3.5%). (rare) Not valuable; having little value. 0.003. A standard 3 + 3 design was used in the dose escalation phase.A 2-stage group sequential design with 20 patients at the MTD was used in the feasibility phase. Beyond calculable or appraisable value; of inestimable worth. Rather than accept that these initial findings were due solely to a lack of protein expression from these genes in the HCCs, we also speculated that there could be a technical problem with regard to the sensitivity of some immunohistochemical reactions in certain tissues when . Inevaluable as a adjective means Unable to be evaluated .. With a median follow-up of 5.9 years, 7 (13%) patients have progressed and 4 (8%) have died (2 with DLBCL). Methods. NCI's Dictionary of Cancer Terms provides easy-to-understand definitions for words and phrases related to cancer and medicine. 537 enrolled patients across all studies. Nucleoside monotherapy vs. combination therapy in HIV infected adults: a randomized double-blind, placebo-controlled trial in persons with CD4 cell counts 200-500. Fifteen evaluable patients had dose-limiting toxicities (DLTs) within the first four cycles. Overall Survival Overall Population OS ) 0 2 4 6 8 10 12 14 16 18 20 22 24 26 28 30 32 1 0.8 0.6 0.4 0.2 0 0.9 0.7 0.5 0.3 0.1 6-month rate 12-month rate 62.3% Methods: Between 1st January 1999 and 31st December 2006 we encountered 832 geriatric patients among a total of 3748 cases. Patients were treated with paclitaxel 175 mg/m 2 IV and carboplatin IP from AUC 5-7 on day 1 and paclitaxel 60 mg/m 2 IP on day 8. , passage=It identified 24 categories of such services, finding that 15 are being degraded or used unsustainably, 4 have been enhanced, and the remaining 5 are unevaluatable . unevaluable: unevaluable (English) Origin & history un- + evaluable Adjective unevaluable (not comparable) Not evaluable. 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